CLSI H 21-A5 PDF

CLSI HA5 Collection, Transport, and Processing of Blood Specimens for Testing Plasma-Based Coagulation Assays and Molecular Hemostasis Assays;. CLSI HA5. Collection, Transport, and Processing of Blood Specimens for Testing Plasma-Based Coagulation Assays; Approved Guideline. HA5 does not provide general guidelines for the performance of coagulation testing. Performance guidelines for specific coagulation assays are addressed.

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Dilutional gross haemolysis releasing cell fluid and content – leading to false lowering of results e. Best Practices in Phlebotomy Errors g laboratory medicine.

Observational study to determine factors associated with blood sample haemolysis in the emergency department. Introduction Haemolysis of blood samples has been documented as the most frequent pre-analytical artefact encountered by laboratories.

You can download and open this file to your own computer but DRM prevents opening this file on another computer, including a networked server. Clin Chem Lab Med. Journal List Clin Biochem Rev v. Where semi-quantitative estimates are in use, their equivalence to a conventional unit e. The interference can be the result of various mechanisms including:.

Example of a Haemolysis Colour Chart which also shows haemolysis index concentration levels across different analytical platforms Courtesy Goce Dimeski, Pathology Queensland. The contents of articles or advertisements in The Clinical Biochemist — Reviews are not to be construed as official statements, evaluations or endorsements by the AACB, its official bodies or its agents.

Ann Acad Med Singapore. Enzymatic – release of enzymes which degrade analytes e. This is a useful website featuring a variety of pre-analytical issues with blood collection, sponsored by Becton Dickinson.

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Factors Affecting Haemolysis, specimencare. The most frequently encountered causes of haemolysis of blood samples include use of inappropriately small gauge needles during phlebotomy and transfer of blood from a syringe into a vacutainer tube via a needle e.

This standard is not included in any packages. Published clinical 21-aa5 studies describing performance requirements for the specific analyte. Statements of opinion in AACB publications are those of the contributors. Please first verify your email before subscribing to alerts.

Areas to consider could include data mining, guidance on how to perform in-house studies and the defining of appropriate action limits.

Consensus Statement for the Management and Reporting of Haemolysed Specimens

Laboratories must have a means to identify affected patient results e. Clinically relevant limits can be sourced from:. Appendix Example of a Haemolysis Colour Chart which also shows haemolysis index concentration levels across different analytical platforms Courtesy Goce Dimeski, Pathology Queensland.

Haemolysis of blood samples has been documented as the most frequent pre-analytical artefact encountered by laboratories. Need more than one copy? Please review our privacy policy. Find articles by Ken Sikaris. Similarly, brown coloured serum due to methaemalbumin, normal results for potassium or the same result from arterial and venous collections should prompt further investigation e. Non standardisation of units.

Where multiple different analytical platforms are in use, for example across a network of laboratories or in a large central laboratory, laboratories must ensure H-Index thresholds are appropriate for each.

Already Subscribed to this document. Additive – as result of greater concentrations of analytes in cells than in plasma e. This standard clsk also available to be included in Standards Subscriptions.

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Consensus Statement for the Management and Reporting of Haemolysed Specimens

Laboratories must be familiar with best practice collection processes. Influence of hemolysis on routine clinical chemistry testing. Laboratories must determine and document at which H-Index level recollection of the sample is appropriate. If a laboratory decides to report affected tests, the H-Index levels used for these purposes must be documented. Support Center Support Center. Tests of the coagulation system are clssi sensitive to storage time and temperatureconcentration of anticoagulant, and surface of containers; attention to these parameters is important.

Whole Blood Analyses S5. The interference can be the result of various mechanisms including: The effect of hemolysis on current troponin assays confounding preanalytical variable? Open in a separate window.

The interference with immunoassays is less frequent than with photometric assays, but is still a significant consideration; one of the most commonly affected immunoassays are the cardiac Troponin assays. Clai clear statement describing the magnitude and direction of the interference must be included. Please first log in with a verified b before subscribing to alerts. A survey of Australian Laboratories enrolled in the RCPA Quality Assurance Programs 2-1a5 an ongoing variation in the management and reporting of haemolysed samples.

Actions in Response to Haemolysis S4. However, these guidelines may also be considered for other sample types e.