Patient Information Leaflet. Package leaflet: Information for the patient. Byetta 5 micrograms solution for injection in pre-filled pen. Byetta 10 micrograms solution . Learn about BYETTA, the BYETTA Pen. in patients with prior severe hypersensitivity reactions to exenatide or to any of the product components. PRODUCT MONOGRAPH. BYETTA® exenatide injection. µg/mL. mL prefilled pen (60 doses of 5 µg/dose) and. mL prefilled pen.
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Exenatide should not be used in patients with type 1 diabetes mellitus or for the treatment of diabetic ketoacidosis.
Careful monitoring of blood glucose is recommended. Let the autoinjector come to room temperature for approximately 15 minutes before administration.
The ijsert is not indicated in infants or neonates. The concurrent use of exenatide with prandial insulin has not been studied. This product information is intended for US Healthcare Professionals only.
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Thin or smaller individuals can use a 45 degree angle to avoid intramuscular injection. In Type 2 diabetes patients with partially intact insulin reserves, octreotide administration may result in decreases in plasma insulin levels and hyperglycemia.
For patients who are to self-administering exenatide, adequate oral as well as written instructions on the use of the injector pen should be supplied before they self-administer a dose.
Hemodialysis Exenatide is not recommended for use in patients with end-stage renal disease ESRD on continuous or intermittent hemodialysis. The hyperglycemic effect of diazoxide is expected to be antagonized by certain antidiabetic agents e. Extended-release exenatide must be injected immediately after suspended in the diluent within the Pen device or the syringe.
Patients with diabetes treated with pegvisomant and antidiabetic agents may be more likely to experience hypoglycemia. Do not store the pen with the needle on, as the medication may leak out or air bubbles may form in the cartridge. Constituents in garlic might have some antidiabetic activity, and may increase serum insulin levels and increase glycogen storage in the liver.
Moderate Green tea catechins have been shown to decrease serum glucose concentrations in vitro. The two peaks represent the hydration and erosion of the microspheres.
Among patients with end-stage renal disease receiving dialysis, the mean exenatide exposure increased by 3. Acetaminophen AUC, Cmax, and Tmax were not significantly changed when acetaminophen was given 1 h before exenatide injection. Alternatively, administer before the 2 main meals of the day, approximately 6 hours or more apart.
Exenatide has not been studied in patients with severe gastrointestinal GI disease, including gastroparesis. In some patients, hypoglycemia can be prolonged. This is followed by a gradual release of exenatide from the microspheres and a second peak around week 6 to 7. Moderate Cases of an increased INR have been reported with the concomitant use of warfarin and exenatide, sometimes associated with bleeding.
Exenatide AUC increased proportionally over the inset dose range of 5 to 10 mcg. Moderate Niacin nicotinic acid interferes with glucose metabolism and can result in hyperglycemia. Go to Healthcare Professional Site.
Type 2 Diabetes Medication | BYETTA® (exenatide) injection
Moderate The concomitant use of clarithromycin and antidiabetic agents can result in significant hypoglycemia. Although specific dose recommendations are not available for most agents, the clinician should consider a dose packsge of the insulin secretagogue or insulin when used in combination with exenatide.
Exenatide also slows gastric emptying thereby reducing the rate at which meal-derived glucose appears in the circulation. Clonidine does not appear to impair recovery from hypoglycemia, and has not been found to impair glucose tolerance in diabetic patients.
Other oral hypoglycemics may also be considered as possible alternatives in some patients.
Byetta (exenatide) dose, indications, adverse effects, interactions from
Use is not recommended. Patients taking antidiabetic agents and receiving bortezomib treatment may require close monitoring of their blood glucose levels and dosage adjustment of their medication.