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BCR Datasheet, PDF – Qdatasheet
Molecular Weight Datasheet Molecular Weight Calculator Enter the chemical formula of a compound to calculate its molar mass and elemental composition: Treatment with sub-micromolar concentrations of MI also leads to markedly reduced expression of Hoxa9 and Meis1, downstream targets of MLL fusion proteins substantially upregulated in MLL leukemias . Bio Calculators Molarity Calculator Molarity Calculator Calculate the mass, volume or concentration required for a solution.
Menin-MLL interaction  Cell-free assay. Histone Methyltransferase Signaling Pathway Map. MI is also very effective in inducing differentiation of MLL leukemia cells and substantially increases expression of CD11b, a myeloid differentiation marker.
MI could substantially improve survival of MLL leukemic mice and does not impair normal hematopoiesis in vivo . Products are for research use only. Media is changed at day 4, viable cell numbers are restored to the original concentration and compounds are re-supplied. Serial Dilutions Concertration start: Chemical formula is case sensitive. In vivo MI has very favorable drug-like properties, including metabolic stability and pharmacokinetic profile in mice. The Selleck dilution calculator is based on the following equation: It shows pronounced growth suppressive activity in a panel of human MLL leukemia cell lines GI50 at nM nM rangebut only a minimal effect in human leukemia cell lines without MLL translocations.
It blocks hematologic tumors in vivo and reduces MLL leukemia tumor burden.
BCR503 Datasheet PDF
Prolonged treatment 38 days with MI induces no toxicity in mice as reflected by no alterations in the body weight and no morphological changes in liver and kidney tissues. Answers to questions you may have can be found in the inhibitor handling instructions.
For viability assays, leukemia cells are plated at relevant concentrations and treated with compounds or 0. The Selleck molarity calculator is based on the following equation:.
We do not sell to patients. Tech Support Answers to questions you may have can be found in the inhibitor handling instructions. These effects are accompanied by reduced c-kit CD expression, a marker associated with leukemia stem cells LSCs.
BCR 503 E6327
The Selleck molarity calculator is based on the following equation: MI has very favorable drug-like properties, including metabolic stability and pharmacokinetic profile in 5003. Not for human use. Dilution Calculator Dilution Calculator Calculate the dilution required to prepare a stock solution. Choose Selective Histone Methyltransferase Inhibitors. Molecular mass molecular weight is the mass of one molecule of a substance and is expressed in the unified atomic mass units u.
The cell growth inhibitory effect of MI is time-dependent, with a pronounced effect achieved after days of treatment.
This equation is commonly abbreviated as: The Selleck dilution calculator is based on the following equation:. This is normal and is due to slight batch-to-batch variations.
Calculate the dilution required to satasheet a stock solution. References  Borkin D, et al. Calculate the mass, volume or concentration required for a solution. For cell differentiation studies, leukemia cells are treated with menin-MLL inhibitors for 7 days, then harvested, washed and incubated with Pacific Blue rat anti-mouse CD11b antibody before being analyzed by flow cytometry.
Topics include how to prepare stock solutions, how to store inhibitors, and issues that need special attention for cell-based assays and animal experiments.