Erythromycin Lactobionate 1g Powder for Solution for Infusion – Summary of Product Characteristics (SmPC) by ADVANZ Pharma. Erythromycin Lactobionate I.V. is a sterile presentation of erythromycin. It is not When administering the product by intermittent infusion do not use solution strengths greater than . includes any possible side effects not listed in this leaflet. Intravenous infusion of mg of erythromycin lactobionate at a constant rate physiologically concentrated or in situations where high dosage of drug can be.
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Skin and soft tissue infections: Cimetidine may inhibit the metabolism of erythromycin which may lead to an increased plasma concentration. Chest pain, fever, malaise. Triazolobenzodiazepines such as triazolam and alprazolam and related benzodiazepines: Drugs that induce CYP3A4 such as rifampicin, phenytoin, carbamazepine, phenobarbital, St John’s Wort may induce the metabolism of erythromycin.
Skin or Soft Tissue Infection ciprofloxacinamoxicillindoxycyclineazithromycinmetronidazolecephalexinMore Known hypersensitivity to erythromycin. Erythromycin Lactobionate 1g Powder for Solution for Infusion. Active ingredient erythromycin lactobionate. There have been isolated reports of transient central nervous system side effects including confusion, seizures and vertigo; however, a cause and effect relationship has not been established.
Be ready to tell or show what was taken, how much, and when lactohionate happened. Clostridium difficile-associated diarrhoea CDAD has been reported with use of nearly all antibacterial agents including erythromycin, and may range in severity from mild diarrhoea to fatal colitis.
Find out more here. Subscribe to receive email notifications whenever new articles are published. Newborn infant birth to 1 month: Name of the medicinal product 2. Erythromycin exerts its antimicrobial action by binding to the 50S ribosomal sub-unit of susceptible microorganisms and suppresses protein synthesis.
Erythromycin Lactobionate – I.V.
Ery-TabEryPedE. Erythromycin antagonises the action of clindamycin, lincomycin and chloramphenicol. Erythromycin can be excreted into breast-milk. This medicine is indicated in severe and immunocompromised cases of infections caused by sensitive organisms where high blood levels are required at the earliest opportunity erythronycin when the oral route is compromised.
QTc interval prolongation, torsades de pointes, palpitations, and cardiac rhythm disorders including ventricular tachyarrhythmias. Appropriate monitoring should be undertaken and dosage should be adjusted as necessary.
Cholestatic hepatitis, jaundice, hepatic dysfunction, hepatomegaly, hepatic failure, hepatocellular hepatitis see section 4. Investigations Increased liver enzyme values.
Erythromycin Lactobionate – I.V. Information –
Recommended Administration Bolus injection IV push is contraindicated Continuous infusion of this medicine is preferred due to the slower infusion rate and lower concentration of erythromycin; however, intermittent infusion at intervals not greater than every six hours is also effective.
Last updated on eMC: There have been reports that etythromycin macrolide antibiotics exposure within 7 weeks lactobonate delivery may be associated with a higher risk of infantile hypertrophic pyloric stenosis IHPS. Do not start, stop, or change the dose of any drug without checking insret your doctor. To email a medicine you must sign up and log in. Lower Respiratory Tract infections: Erythromycin should not be used during and two weeks after treatment with CYP3A4 inducers. For Continuous Infusion of 1 gram dose: Ear and labyrinth disorders: Alternative Step 2 diluents: There have been published reports suggesting when oral erythromycin is given concurrently with theophylline there is a significant decrease in erythromycin serum concentrations.